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In the context of Diabetes Insipidus (DI), the most relevant electrolyte that may decrease is sodium. DI leads to an inability of the kidneys to concentrate urine, resulting in excessive urination and a significant loss of free water. This can lead to a relative hypernatremia initially due to water loss; however, if excessive water is lost and not adequately replaced, the body's sodium levels may eventually drop as water continues to be lost. In severe cases, this imbalance may lead to hyponatremia, as the body struggles to manage its electrolyte concentrations when fluid levels fluctuate dramatically.

Monitoring and correcting for sodium levels is crucial in managing patients with DI, especially in cases where they may be experiencing hypovolemia or other complications related to electrolyte imbalances. This highlights the importance of recognizing the connections between fluid loss in DI and its impact on serum sodium levels, which can significantly affect patient outcomes.